DIGESTIVE SYSTEM : PHARYNX, ESOPHAGUS AND STOMACH-ENGLISH

                                                          

 DIGESTIVE SYSTEM : PHARYNX, ESOPHAGUS AND STOMACH-ENGLISH

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PHARYNX, ESOPHAGUS  AND STOMACH-

 

       The digestive system is also known as the gastrointestinal system or the alimentary canal or  GIT. This vast system is approximately 10 m long. It travels the length of the body from the mouth through the thoracic, abdominal and pelvic cavities, where it ends at the anus. We will cover it in multiple lectures. Today we are going to discuss the anatomy and physiology of pharynx, esophagus and stomach.

 

PHARYNX-

       The pharynx consists of three parts: the oropharynx, the nasopharynx and the laryngopharynx. The nasopharynx is considered a structure of the respiratory system. The oropharynx and the laryngopharynx are passages for both food and respiratory gases . The wall of pharynx is made up of adventitia, muscles, submucosa and mucosa. The mucosa varies slightly in the different regions.

 

DIGESTIVE FUNCTIONS OF PHRARYNX

       During the pharyngeal phase of swallowing reflex action is initiated in response to the sensation of the food bolus in the oropharynx. This reflex is coordinated by the swallowing centre in the medulla oblongata, and the motor response is contraction of the muscles of the pharynx. The soft palate elevates, closing off the nasopharynx and preventing the food bolus from using this route. The larynx moves up and moves forward, allowing the epiglottis to cover the entrance to the larynx so the food bolus cannot move into the respiratory passages.

 

ESOPHAGUS-

       The esophagus (food pipe) is a  fibromuscular tube forming part of the gastrointestinal tract, which passes food and liquid aided by peristaltic contractions from the pharynx to the stomach.

       The esophagus generally starts around the level of the sixth cervical vertebra (C6) and travels behind the trachea and the heart, passes through the diaphragm and enters in the  stomach at the level of the eleventh thoracic vertebra (T11). The overall length of the esophagus is about 25 cm

       The superficial layer of the esophagus is known as the adventitia. The adventitia attaches the esophagus to surrounding structures. Esophagus has two sphincters—the upper esophageal sphincter (UES)  which consists of skeletal muscle, and the lower esophageal sphincter (LES), which consists of smooth muscle.

 

FUNCTIONS OF ESOPHAGUS

       The esophagus secretes mucus and transports food into the stomach. It does not produce digestive enzymes, and it does not take part in absorption. Food is transported by peristalsis movement of esophagus.

 

STOMACH-

       The stomach is a J-shaped dilated portion of the alimentary tract situated in the epigastric, umbilical and left hypochondriac regions of the abdominal cavity. It lies between the esophagus superiorly and the duodenum of the small intestine inferiorly.

       The entrance to the stomach from the oesophagus is through  the lower esophageal sphincter or cardiac sphincter. This leads to a small area within the stomach called the cardiac region or cardia. The fundus is the dome‐shaped region in the superior part of the stomach. The body region occupies the space between the lesser and greater curvature of the stomach, and the pyloric region narrows into the pyloric canal.

       The pyloric sphincter controls the exit of chyme from the stomach into the small intestine. Chyme is the name given to the food bolus as it leaves the stomach.

 

WALL OF THE STOMACH

       The stomach has the same four layers of tissue as the digestive tract, but with some differences. The muscularis contains three layers of smooth muscle instead of two. It has longitudinal, circular and oblique muscle fibres. The extra muscle layer facilitates the churning, mixing and mechanical digestion of food that occurs within the stomach, as well as supporting the onward journey of the food by peristalsis.

       The mucosa within the stomach is also different from the rest of the digestive tract. When the stomach is empty, the mucosal epithelia falls into long folds known as rugae. The rugae fill out when the stomach is full. Numerous gastric glands are situated below the surface in the mucous membrane and open on to it .They consist of specialised cells that secrete gastric juice into the stomach.

       Stomach is like a balloon it’s minimum volume is as little as 50ml. Normal volume after eating full meal it has capacity of 1500-2000ml. Maximum capacity is 4000 ml. About 2 litres of gastric juice are secreted daily by specialised secretory glands in the mucosa It consists of mucus secreted by mucous neck cells in the glands and surface mucous cells on the stomach surface inactive enzyme precursors: pepsinogens secreted by chief cells in the glands.

 

FUNCTIONS OF GASTRIC JUICE-

       Water further liquefies the food swallowed.

       Hydrochloric acid: – acidifies the food and stops the action of salivary amylase, – kills ingested microbes, – provides the acid environment needed for effective digestion by pepsins.

       Pepsinogens are activated to pepsins by hydrochloric acid and by pepsins already present in the stomach. These enzymes begin the digestion of proteins, breaking them into smaller molecules.

       Intrinsic factor (a protein) is necessary for the absorption of vitamin B12 from the ileum.

       Mucus prevents mechanical injury to the stomach wall by acting as a barrier between the stomach wall and the corrosive gastric juice.  Hydrochloric acid is present in potentially damaging concentrations and pepsins would digest the gastric tissues.

        

PHYSIOLOGY OF GASTRIC JUCE SECRETION-

       There is always a small quantity of gastric juice present in the stomach, even when it contains no food. This is known as fasting juice. Secretion reaches its maximum level about 1 hour after a meal then declines to the fasting level after about 4 hours.  There are three phases of secretion of gastric juice- cephalic phase, gastric phase and intestinal phase.

       1. The cephalic phase: The sight, taste or smell of food stimulates the secretion of gastric juice.

       2. The gastric phase: When food enters the stomach, the hormone gastrin is secreted into the bloodstream, and this stimulates the secretion of gastric juice. The secretion of hydrochloric acid reduces the pH of the stomach contents, and when the pH drops below 2 the secretion of gastrin is inhibited.

       3. The intestinal phase: As the acidic contents of the stomach enter the duodenum of the small intestine the hormones secretin and cholecystokinin (CKK) are secreted. These hormones also act to reduce the secretion of gastric juice and gastric motility. The rate of gastric emptying depends on the size and content of the meal. A large meal takes longer than a small meal. Liquids quickly pass through the stomach. (Normally in 4 hours)

 

FUNCTIONS OF STOMACH-

       Functions of stomach include:

       Temporary storage allowing time for the digestive enzymes, pepsins, to act on the food.

       Chemical digestion – pepsins convert proteins to polypeptides

       Mechanical breakdown – the three smooth muscle layers enable the stomach to act as a churn, gastric juice is added and the contents are liquefied to chyme.

        Absorption - limited absorption of water, alcohol and some lipid-soluble drugs. preparation of iron for absorption further along the tract by the acid environment of the stomach.  

       Non-specific defence  – non specific defence is provided by hydrochloric acid in gastric juice by killing microbes. 

       Secretion of the hormone gastrin and  enzyme pepsinogen

 

       Production and secretion of intrinsic factor needed for absorption of vitamin B12 in the terminal ileum.

       Regulation of the passage of gastric contents into the duodenum. When the chyme is sufficiently acidified and liquefied, the pylorus forces small jets of gastric contents through the pyloric sphincter into the duodenum.

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